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Evolutionary aspects of Alzheimer's disease. Major role of the Apolipoprotein E
Škubica, Patrik ; Daňková, Pavlína (advisor) ; Jirák, Roman (referee)
Alzheimer's disease is one of the most discussed conditions, due to its huge social and economic consequences. Whereas molecular and genetic aspects causing early onset of the disease are relatively well known, it still remains to be clearly shown how genetic risks and environmental factors interact to ultimately cause the late onset form. Major molecular-genetic factors affecting risk of developing Alzheimer's disease are APOE gene and its product apolipoprotein E. This gene occurs in humans in three common variants that differ among each other in exon sequence by one single nucleotide polymorphism. Similar difference exists between human and mammal APOE gene that served as an origin for human forms. This thesis discusses possible evolutionary scenarios of APOE gene and links acquired information to molecular and environmental ascpects of Alzheimer's disease.
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Contemporary Scientific Knowledges and its Pedagogical Transformation by Way of Example of Human Evolution's Topic
Dvořáková, Radka ; Vančata, Václav (advisor) ; Zrzavý, Jan (referee) ; Škoda, Jiří (referee)
This thesis is about the pedagogical transformation of modern scientific knowledge from the field of palaeoanthropology and evolution anthropology to the teaching about human at the first and high schools in the Czech Republic. The main objective of this thesis (realised through four constituent research studies) is to analyse and to describe this complex and multilevel process. The first step was the content analyse of 32 textbooks. We also analysed the framework of the whole process. We realise questionnaire survey among 217 teachers and also interview with 10 teachers. The last research study about student's attitude and knowledge was questionnaire survey among 660 students. We found that there are no serious obstacles in the teaching of (human) evolution from the field of believers in the Czech Republic like in some other countries. It takes usually few decades to get new findings and conceptions into the textbooks, despite it some exceptions exist. Teachers seem to be the key participants of the process of pedagogical transformation. It is not only about the information they teach in their lessons but also about the way how they teach and about the attitude the build-up towards the topic among their students.
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Evolutionary aspects of (epi)genetic determination of laterality with a special focus on upper limb
Holoubková, Tereza ; Daňková, Pavlína (advisor) ; Struška, Michal (referee)
Handedness is one of the most distinct asymmetries of the human body. There is approximately 90 % of right-handers in the population, which is the strongest bias in handedness among all primates. Handedness is connected with lateralization of brain for language and is determined both genetically and by the environment. Genetic determination of the handedness has not been yet figured out, although there are many candidate genes and regions. In addition to candidate genes, the genetic determination is shaped by the epigenetic mechanisms and the role of testosterone. Handedness occurred alongside the beginning of the human population development, approximately in the Middle Pleistocene, with the same percentage of left-handers as today. Handedness polymorphism is maintained in the population based on the frequency-dependent model because of the advantages and disadvantages associated with left-handedness.
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Analysis of the topic Human Origin and Evolution in the Textbooks and the Workbooks for Elementary School
Hoffmannová, Valérie ; Dvořáková, Radka (advisor) ; Chlebounová, Irena (referee)
(AJ) The main aim of this diploma thesis is to analyze the learning tasks related to the topic of the origin and development of the human species in textbooks and workbooks for the second grade of primary school. Textbooks and workbooks of biology and history were selected for analysis. The learning tasks were categorized into individual categories of Tollinger taxonomy and Bloom's original taxonomy. The results of this classification were used to compare older and newer editions of selected textbooks and workbooks. I also found out the difficulty of tasks in each publications. This analysis revealed that teaching tasks from lower taxonomic categories (for both taxonomies), which do not high demands of cognitive operations, are more represented. Furthermore, this work deals how extent the topic in individual publications. Further analyzes revealed that teaching tasks of the origin and development of human species are more represented in the textbooks and workbooks of history. The results of this work could help teachers to find way in the offer of available textbooks and workbooks and help select a suitable publication to teach the topic of the origin and development of the human species. Key words: analysis, biology, Bloom's taxonomy, history, human evolution, Tollinger's taxonomy, textbooks, workbook
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Contemporary Scientific Knowledges and its Pedagogical Transformation by Way of Example of Human Evolution's Topic
Dvořáková, Radka ; Vančata, Václav (advisor) ; Zrzavý, Jan (referee) ; Škoda, Jiří (referee)
This thesis is about the pedagogical transformation of modern scientific knowledge from the field of palaeoanthropology and evolution anthropology to the teaching about human at the first and high schools in the Czech Republic. The main objective of this thesis (realised through four constituent research studies) is to analyse and to describe this complex and multilevel process. The first step was the content analyse of 32 textbooks. We also analysed the framework of the whole process. We realise questionnaire survey among 217 teachers and also interview with 10 teachers. The last research study about student's attitude and knowledge was questionnaire survey among 660 students. We found that there are no serious obstacles in the teaching of (human) evolution from the field of believers in the Czech Republic like in some other countries. It takes usually few decades to get new findings and conceptions into the textbooks, despite it some exceptions exist. Teachers seem to be the key participants of the process of pedagogical transformation. It is not only about the information they teach in their lessons but also about the way how they teach and about the attitude the build-up towards the topic among their students.
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Evolutionary aspects of Alzheimer's disease. Major role of the Apolipoprotein E
Škubica, Patrik ; Daňková, Pavlína (advisor) ; Jirák, Roman (referee)
Alzheimer's disease is one of the most discussed conditions, due to its huge social and economic consequences. Whereas molecular and genetic aspects causing early onset of the disease are relatively well known, it still remains to be clearly shown how genetic risks and environmental factors interact to ultimately cause the late onset form. Major molecular-genetic factors affecting risk of developing Alzheimer's disease are APOE gene and its product apolipoprotein E. This gene occurs in humans in three common variants that differ among each other in exon sequence by one single nucleotide polymorphism. Similar difference exists between human and mammal APOE gene that served as an origin for human forms. This thesis discusses possible evolutionary scenarios of APOE gene and links acquired information to molecular and environmental ascpects of Alzheimer's disease.
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